Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2020 Publisher: Aurum Pharmaceuticals Ltd, Bampton Road, Harold Hill, Romford, RM3 8UG, UK
Calcium Chloride Injection is indicated for use in Cardio-pulmonary Resuscitation where there is also hyperkalaemia or hypocalcaemia or calcium channel block toxicity.
It is also used for the treatment of hypocalcaemia and of calcium deficiency states (a decrease in plasma-calcium concentration below the normal range of 2.15-2.60 mmol/L) as a result of impaired or reduced absorption from the gastrointestinal tract, increased deposition in bone, or to excessive losses, for instance during lactation.
Additionally, hypocalcaemia may develop during transfusions utilising citrated blood or during long-term parenteral nutrition unless prophylactic calcium supplementation is employed. Other causes of hypocalcaemia include decreased parathyroid hormone activity, vitamin D deficiency and hypomagnesaemia.
This medicinal product is not intended to deliver volumes of less than 2 mL
In Cardiopulmonary Resuscitation (CPR) a single dose of 10ml (10% w/v) should be considered, according to the algorithm recommended by the European Resuscitation Council & the Resuscitation Council (UK).
Adults in acute hypocalcaemia, a typical dose is 2.25 to 4.5 mmol (approximately 3-7ml of a 10% w/v solution) of calcium given by slow intravenous infusion and repeated as required.
This medicine is not recommended for use in children.
For slow intravenous infusion only. Not for intramuscular use, or subcutaneous use
An overdose of Calcium Chloride would lead to hypercalcaemia and produce the signs and symptoms described above (see Section 4.8).
Initial management of hypercalcaemia should include withholding calcium administration, this will usually resolve mild hypercalcaemia in asymptomatic patients, provided renal function is adequate. When serum calcium concentrations are greater than 12mg per 100ml, immediate measures may be required such as rehydration by either the oral or intravenous route. In severe hypercalcaemia, administration of sodium chloride by intravenous infusion to expand the extracellular fluid may be necessary.
Intravenous rehydration may be given with, or followed by, furosemide or other loop diuretics to increase calcium excretion. Thiazide diuretics should be avoided as they may increase the renal absorption of calcium.
Other drugs which may be used if this treatment proves unsuccessful include calcitonins, the bisphosphonates, chelating agents, corticosteroids and plicamycin.
Phosphates may be useful, but should be given by mouth and only to patients with low serum phosphate concentrations and normal renal function.
Haemodialysis may be considered as a last resort.
3 years.
Do not store above 25°C.
Type 1 glass pre-filled syringe, containing 10ml of a 10% w/v Calcium Chloride sterile solution for slow intravenous infusion only.
Discard any contents after use in appropriate manner.
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