Source: Health Products Regulatory Authority (IE) Revision Year: 2020 Publisher: Pinewood Laboratories Ltd, Ballymacarbry, Clonmel, Co. Tipperary, Ireland
Aspirin is an analgesic and antipyretic with anti-inflammatory properties.
Aspirin inhibits prostaglandin synthetase.
Aspirin inhibits platelet aggregation.
Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation when they are dosed concomitantly. In one study, when a single dose of ibuprofen 400mg was taken within 8 h before or within 30 min after immediate release aspirin dosing (81mg), a decreased effect of ASA on the formation of thromboxane or platelet aggregation occurred.
However, the limitations of these data and the uncertainties regarding extrapolation of ex vivo data to the clinical situation imply that no firm conclusions can be made for regular ibuprofen use, and no clinically relevant effect is considered to be likely for occasional ibuprofen use.
A
Absorption is more rapid in patients with achlorhydria and also following administration of polysorbates and antacids.
To prevent stomach irritation, CAPRIN 75mg tablets have a special enteric coating so that aspirin is not released until it has passed through the stomach.
Aspirin/protein binding to a small extent.
Not applicable.
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