Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2020 Publisher: Pfizer Limited, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom
Pharmacotherapeutic group: bile acid sequestrants
ATC code: C10AC02
Ion exchange resin which lowers plasma cholesterol through binding with bile acids in the intestinal lumen.
Colestid is not absorbed; its action is limited to the lumen of the gastro-intestinal tract, and it is passed in the faeces. It binds bile acids in the intestinal lumen and causes them to be excreted in the faeces together with the polymer. When the enterohepatic circulation of bile acids is interrupted, cholesterol conversion to bile acids is enhanced and plasma cholesterol levels are thereby lowered.
Both clinical and animal studies with Colestid have provided no evidence of drug related intestinal neospasms. Colestid is not mutagenic in the Ames test.
Reproduction and teratologic studies in animals gave no evidence of drug toxicity in parents or offspring.
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