COVERAM Tablet Ref.[50881] Active ingredients: Amlodipine Perindopril

The active components of COVERAM are perindopril arginine and amlodipine besilate.

Each COVERAM 5/5 tablet contains 5 mg of perindopril arginine and 5 mg of amlodipine (as besilate^‡).

Each COVERAM 5/10 tablet contains 5 mg of perindopril arginine and 10 mg of amlodipine (as besilate^‡).

Each COVERAM 10/5 tablet contains 10 mg of perindopril arginine and 5 mg of amlodipine (as besilate^‡).

Each COVERAM 10/10 tablet contains 10 mg of perindopril arginine and 10 mg of amlodipine (as besilate^‡).

Excipient with known effect: contains sugars as lactose

For the full list of excipients, see section 6.1 – List of excipients.

^‡ Amlodipine doses are given as active base

Perindopril arginine

Perindopril arginine has the chemical name, L-arginine (2S,3aS,7aS)1[(2S)2[[(1S)1 (ethoxycarbonyl)butyl]amino] propanoyl]octahydro-1H-indole-2-carboxylate. It is a dipeptide monoacid monoester with a perhydroindole group and no sulfydryl radical. Perindopril arginine is a white powder, readily soluble in purified water, slightly soluble in 95% ethanol and practically insoluble in chloroform. Perindopril has five asymmetric centres. The drug is synthesised stereoselectively so that it is a single enantiomer (all S stereochemistry).

Chemical structure:

CAS number: 612548-45-5

Amlodipine besilate

Amlodipine besilate is a dihydropyridine derivative, and has the following chemical name: 3-Ethyl 5-methyl (4RS)2[(2-aminoethoxy)methyl]4(2-chorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate. Amlodipine besilate is chiral and present as a racemate. It is a white crystalline powder and is slightly soluble in water and sparingly soluble in ethanol.

Chemical structure:

CAS number: 111470-99-6