Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2011 Publisher: Ferring Pharmaceuticals Ltd., Drayton Hall, Church Road, West Drayton, UB7 7PS, United Kingdom
Desmopressin is a structural analogue of vasopressin in which the antidiuretic activity has been enhanced by the order of 10, while the vasopressor effect has been reduced by the order of 1500. The clinical advantage of this highly changed ratio of antidiuretic to vasopressor effect is that clinically active antidiuretic doses are far below the threshold for a vasopressor effect.
Like vasopressin, Desmopressin also increases concentrations of Factor VIII:C, Factor VIII:Ag and Plasminogen Activator.
Following intravenous injection, plasma concentrations of Desmopressin follow a biexponential curve. The initial fast phase of a few minutes duration and with a half life of less than 10 minutes is thought mainly to represent the diffusion of Desmopressin from plasma to its volume of distribution. The second phase with a half life of 51-158 minutes represents the elimination rate of Desmopressin from the body.
As a comparison, the half life of vasopressin is less than 10 minutes.
In vitro, in human liver microsome preparations, it has been shown that no significant amount of desmopressin is metabolised in the liver and thus human liver metabolism in vivo is not likely to occur.
It is unlikely that desmopressin will interact with drugs affecting hepatic metabolism, since desmopressin has been shown not to undergo significant liver metabolism in in vitro studies with human microsomes. However, formal in vivo interaction studies have not been performed.
There are no pre-clinical data of relevance to the prescriber which are additional to those already included in other sections of the SPC.
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