Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2018 Publisher: Aurum Pharmaceuticals Ltd, Bampton Road, Harold Hill, Romford, Essex, RM3 8UG
Natural opium alkaloids
ATC Code: N07BC06
Diamorphine is a powerful narcotic analgesic obtained from opium which acts mainly on the central nervous system and smooth muscle. It can provoke the release of endogenous histamine and thereby induce catecholamine release.
Diamorphine also has a powerful cough suppressant effect.
Oral administration of diamorphine results in measurable blood concentrations of morphine but not diamorphine or 6-acetylmorphine. The amount of circulating morphine provided by an oral dose of diamorphine was only 79% of that available from an equal amount of morphine.
Preclinical information has not been included because the safety profile of diamorphine hydrochloride has been established after many years of clinical use. Please refer to section 4.
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