Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2011 Publisher: SERB, 53 rue Villiers de lIsle Adam, F-75020, PARIS, FRANCE
Cyanide blocks intracellular respiration by binding to cytochrome oxidase. Dicobalt Edetate Injection forms a stable complex with the cyanide thereby acting as an antidote.
Only very limited data are available. Intravenous infusion of Dicobalt Edetate Injection is likely to result in rapid distribution in the extracellular fluid compartment. Excretion is entirely via the kidneys within 24 hours and it is not metabolised.
There are no pre-clinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.
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