Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2016 Publisher: L.C.M. Ltd., Linthwaite Laboratories, Huddersfield, HD7 5QH
Pharmacotherapeutic group: Osmotically acting laxatives
ATC code: A06AD04
Magnesium sulfate is a saline purgative.
It can be employed locally in various inflammatory conditions, due to its osmotic action.
When a dilute solution of magnesium sulfate is taken by mouth, the absorption of water from the intestine is reduced, and the bulky fluid contents distend the bowel. Active peristalsis is excited and evacuation of the contents of the intestine results.
Magnesium salts cause the secretion of cholecystokinin from the duodenal mucosa, it has been suggested that cholecystokinin – mediated pancreatic secretion and increased secretion and motility of the small intestine and colon may contribute to the cathartic effect
Magnesium sulfate causes bowel evacuation normally within 2-4 hours.
No data of relevance which is additional to that already included in other sections of the SPC.
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