ESTRACYT Capsule Ref.[8734] Active ingredients: Estramustine

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2019  Publisher: Pfizer Limited, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

Therapeutic indications

Carcinoma of the prostate, especially in cases unresponsive to, or relapsing after, treatment by conventional oestrogens (stilboestrol, polyoestradiol phosphate etc.) or by orchidectomy.

Posology and method of administration

Posology

Adults and the elderly

Dosage range may be from 1 to 10 capsules a day by mouth. The capsules should be taken not less than 1 hour before or 2 hours after meals. Milk, milk products or drugs containing calcium, magnesium or aluminium (e.g. antacids) must not be taken simultaneously with Estracyt capsules (see section 4.5). Standard starting dosage is 4-6 capsules a day in divided doses with later adjustment according to response and gastrointestinal tolerance.

Paediatric population

Estracyt should not be administered to children.

Overdose

There is no specific antidote. Treatment is symptomatic and supportive (as necessary the gastric contents should be evacuated by gastric lavage) and in the event of dangerously low red cell, white cell or platelet count, whole blood should be given as necessary. Liver function should be monitored.

Shelf life

36 months.

Special precautions for storage

Store below 25°C.

Nature and contents of container

Brown glass bottle containing 100 capsules.

Special precautions for disposal and other handling

No special requirements.

Any unused medicinal product or waste product should be disposed of in accordance with local requirements.

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