EXBLIFEP Solution for injection Ref.[108537] Active ingredients: Cefepime Cefepime and Enmetazobactam

EXBLIFEP (cefepime and enmetazobactam) for injection is a combination product that contains cefepime, a cephalosporin antibacterial drug, and enmetazobactam, a beta-lactamase inhibitor, for intravenous administration.

Cefepime, present as cefepime hydrochloride monohydrate, is a white to pale yellow powder. The chemical name for cefepime is (6R,7R,Z)7(2-(2-aminothiazol-4-yl)2(methoxyimino)acetamido)3((1-methylpyrrolidinium-1-yl)methyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate. The empirical formula of cefepime hydrochloride monohydrate is C₁₉H₂₄N₆O₅S₂·2HCl·H₂O, the molecular weight is 571.50, and its chemical structure is:

Figure 1. Structure of Cefepime:

Enmetazobactam is a white to off-white powder, with a molecular weight of 314.38. The chemical name for enmetazobactam is (2S,3S,5R)-3-methyl-3-((3-methyl-1H-1,2,3-triazol-3-ium-1-yl)methyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide. Its empirical formula is C₁₁H₁₄N₄O₅S and its chemical structure is:

Figure 2. Structure of Enmetazobactam:

EXBLIFEP 2.5 grams (cefepime and enmetazobactam) for injection is supplied as a white to off-white sterile powder for reconstitution. Each vial contains 2 grams of cefepime (equivalent to 2.3 g of cefepime hydrochloride), 0.5 grams of enmetazobactam, and 1.414 grams of L-arginine.