Source: Pharmaceutical Benefits Scheme (AU) Revision Year: 2023 Publisher: Pfizer Australia Pty Ltd, Level 17, 151 Clarence Street, Sydney NSW 2000, Toll Free Number: 1800 675 229, www.pfizermedinfo.com.au
Piroxicam is a NSAID which also possesses analgesic and antipyretic properties. While its mode of action is not fully understood, independent studies in vitro as well as in vivo have shown that piroxicam interacts at several steps in the immune and inflammation responses through the following mechanisms:
Piroxicam has been shown to inhibit chemotaxis of polymorphonuclear leucocytes and the migration of leucocytes in canine synovitis test. The drug also inhibits collagen-induced platelet aggregation. It is established that piroxicam does not act by pituitary-adrenal axis stimulation. Studies in vitro have not revealed any negative effect on cartilage metabolism.
Subacute and chronic toxicity studies have been carried out in rats, mice, dogs, and monkeys. The pathology most often seen was that characteristically associated with the animal toxicology of NSAIDs: renal papillary necrosis and gastrointestinal lesions.
No data available.
Piroxicam is well absorbed following oral administration. The extent and rate of absorption are not influenced by administration in the fasting state. The plasma half-life is approximately 36-45 hours in man and stable plasma concentrations are maintained throughout the day on once daily dosage. After repeated administration, plasma concentrations increase for five to seven days, by which time a steady state is reached which is not exceeded following further constant daily drug administration.
Piroxicam is highly protein bound (99%) and therefore might be expected to displace other protein bound drugs (see Section 4.5 Interactions with other medicines and other forms of interactions, Protein-bound Agents).
Piroxicam is extensively metabolised and less than 5% of the daily dose is excreted unchanged in urine and faeces. One important metabolic pathway is hydroxylation of the pyridyl ring of the piroxicam side chain followed by conjugation with glucuronic acid and urinary elimination. Approximately 5% of the dose is metabolised to and excreted as saccharin.
No data available.
No data available.
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