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Faropenem is contraindicated in patients with known hypersensitivity to any of the components of this product or to other drugs in the same class, or in patients who have demonstrated anaphylactic reactions to beta-lactams.
Faropenem should be administered with caution in the following:
1. Patients with a past history of hypersensitivity to penicillin, cephem or carbapenem drugs.
2. Patients with a family history of atopy.
3. Patients with renal impairment. The dosage should be reduced or the interval between doses should be increased.
4. Geriatric patients.
5. Patients with poor oral intake or poor general state (since there are cases that show symptoms of vitamin K deficiency, proper monitoring should be done).
Faropenem is generally well tolerated. The most frequently reported adverse reactions are diarrhea, abdominal pain, loose bowel movements, nausea and rash.
It has been reported that in animal studies (rat), the concentration of faropenem in the blood increases. It is due to the obstruction of metabolic fermentation by cilastatin.
It has been reported in animal studies (dog), that the kidney toxicity of faropenem increases.
It has been reported that due to joint usage with carbapenem drugs (meropenem, panipenem and imipenem-cilastatin sodium) the concentration of valproic acid in the blood reduces, and there is a recurrence of epileptic fits.
Safety regarding therapy during pregnancy has not been established. In pregnant women or expectant mothers, the medicine should be given only if the benefits of the treatment are greater than the risks involved.
Faropenem is excreted in human milk. Therefore, Faropenem should be given to nursing mothers only if the benefits outweigh the risks.
Safety regarding therapy in infants has not been established.
The half-life of faropenem is prolonged in the elderly and this may be due to a decline in kidney functions, which results in high plasma concentrations.
Therefore, in the elderly, start with a dose of 150 mg and monitor the patient for any undesirable effects.
If diarrhea and loose bowel movements appear, stop the medicine, monitor correctly and take appropriate measures. There is a tendency of hemorrhage dueto vitamin K deficiency in the elderly.
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