FORANE Liquid for inhalation Ref.[10816] Active ingredients: Isoflurane

FORANE (isoflurane, USP), a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is:

Some physical constants are:

Molecular weight: 184.5
Boiling point at 760 mm Hg: 48.5°C
Refractive index n²⁰_D: 1.2990-1.3005
Specific gravity 25°/25°C: 1.496

Vapor pressure in mm Hg**:

20°C – 238
25°C – 295
30°C – 367
35°C – 450

^** Equation for vapor pressure calculation:

log₁₀P_vap = A + B/T where:

A = 8.056
B = -1664.58
T = °C + 273.16 (Kelvin)

Partition coefficients at 37°C:

Partition coefficients at 25°C – rubber and plastic:

Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures), and does not attack aluminum, tin, brass, iron or copper.