Source: Health Products Regulatory Authority (ZA) Revision Year: 2022 Publisher: Acino Pharma (Pty) Ltd, 106 16th Road, Midrand, 1686
Pharmacological classification: A 11.5 Laxatives
Pharmacotherapeutic group: Osmotic laxative
ATC code: A06AD15 (A: digestive system and metabolism)
High molecular weight (4000) macrogols are long linear polymers which retain water molecules by means of hydrogen bonds. When administered by the oral route, they lead to an increase in volume of intestinal fluids. The volume of unabsorbed intestinal fluid accounts for the laxative properties of the solution.
The pharmacokinetic data confirm that macrogol 4000 undergoes neither gastrointestinal resorption nor biotransformation following oral ingestion.
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