Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2018 Publisher: LEO Laboratories Limited, Horizon, Honey Lane, Hurley, Maidenhead, Berkshire, SL6 6RJ, UK
Pharmacotherapeutic group: Steroid antibacterials
ATC code: J01XC01
Fusidic acid and its salts are potent anti-staphylococcal agents with unusual ability to penetrate tissue. Bactericidal levels have been assayed in bone and necrotic tissue. Concentrations of 0.03-0.12 mcg/ml inhibit nearly all strains of staphylococcus aureus. Fusidic acid is active against staphylococcus epidermidis and methicillin resistant staphylococci.
Blood levels are cumulative, reaching concentrations of 50-100 mcg/ml after oral administration of 1.5 g daily for 3 to 4 days.
Fucidin is excreted mainly in the bile, little or none being excreted in the urine.
In severe or deep-seated infections and when prolonged therapy may be required, systemic Fucidin should generally be given concurrently with other anti-staphylococcal antibiotic therapy.
There are no pre-clinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.
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