Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2018 Publisher: Wockhardt UK Ltd, Ash Road North, Wrexham, LL13 9UF, UK
Heparin is an anticoagulant and acts by inhibiting thrombin and by potentiating the naturally occurring inhibitors of activated Factor X (Xa).
As heparin is not absorbed from the gastrointestinal tract and sublingual sites it is administered by injection. After injection heparin extensively binds to plasma proteins.
Heparin is metabolised in the liver and the inactive metabolic products are excreted in the urine.
The half life of heparin is dependent on the dose.
There are no pre-clinical data of relevance to the prescriber which are additional to those already included in other sections.
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