Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2018 Publisher: Amdipharm UK Limited, Capital House, 85 King William Street, London EC4N 7BL, UK
Hydrocortisone is a glucocorticoid with anti-inflammatory properties.
Hydrocortisone is readily absorbed from the gastrointestinal tract and peak blood concentrations are attained in about an hour. It is more than 90% bound to plasma proteins.
Hydrocortisone is metabolised in the liver and most body tissues to hydrogenated and degradated forms such as tetrahydrocortisone and tetrahydrocortisol.
These are then excreted in the urine, mainly conjugated as glucuronides, together with a very small proportion of unchanged hydrocortisone.
There are no preclinical data of relevance to the prescriber which are additional to those in other sections of the SPC.
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