Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2018 Publisher: Martindale Pharmaceuticals Ltd, Bampton Road, Romford, RM3 8UG, England
Pharmacotherapeutic group: Ophthalmologicals: other ophthalmologicals
ATC code: S01XA20
Hypromellose is a soothing emollient solution with properties and uses similar to those of methylcellulose. Its advantages over methylcellulose are that mucilages of hypromellose have greater clarity and fewer undispersed fibres are usually present. It prolongs the action of medicated eye drops and is used as artificial tears to prevent damage to the cornea in dry eye syndromes.
This product is a sterile, isotonic, buffered solution of Hypromellose. It is used as a substitute for natural tears.
Not applicable to topical (ophthalmic) preparations.
Hypromellose is an inert substance. It has no pharmacological activity and not absorbed systemically. Hence, the pharmacokinetic properties have not been studied.
Hypromellose is an inert substance and is not expected to be absorbed systemically. Hence, although no systemic toxicity studies have been conducted it is not expected to demonstrate any systemic toxicity or to have any effect on reproductive processes.
Similarly no specific local ocular toxicity or irritation studies have been conducted; however no adverse effects are anticipated. Indeed, hypromellose ophthalmic solution is used as a control in some ophthalmic drugs studies because of the acknowledged low level of toxicity.
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