Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2020 Publisher: Wockhardt UK Ltd, Ash Road North, Wrexham, LL13 9UF, U.K.
Pharmacotherapeutic group: Insulins and analogues for injection, intermediate-acting
ATC Code: A10AC03
Insulin output from the pancreas of a healthy person is about 50 units per day, which is sufficient to maintain the fasting blood sugar concentration in the range 0.8 + 0.2mg/ml. In diabetes mellitus, the blood sugar rises in an uncontrolled manner. Parenterally administered insulin causes a fall in blood sugar concentration and increased storage of glycogen in the liver. In the diabetic it raises the respiratory quotient after a carbohydrate meal and prevents the formation of ketone bodies. The rise in blood sugar concentration caused by adrenaline and corticosteroids, glucagon and posterior pituitary extract is reversed by insulin.
Insulin is rapidly absorbed from subcutaneous tissue or muscle following injection.
Insulin is metabolised mainly in the liver and a small amount is excreted in the urine.
The plasma half life is 4 to 5 minutes. The half life after subcutaneous injection is about 4 hours and after intramuscular injection about 2 hours.
There are no preclinical data of relevance to the prescriber which are additional to those already included in other sections.
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
