Source: Υπουργείο Υγείας (CY) Revision Year: 2022 Publisher: Remedica Ltd, Aharnon Str., Limassol Industrial Estate, 3056 Limassol, Cyprus
Pharmacotherapeutic group: Antiinflammatory and antirheumatic products, Antiinflammatory and antirheumatic products, non-steroids
ATC code: M01AB01
Indometacin has anti-inflammatory, antipyretic and analgesic effects, it is an inhibitor of prostaglandin synthetase.
Indometacin is readily and almost completely absorbed on oral administration, and peak plasma levels are reached in ½ to 2 hours. Absorption is slowed but remains virtually complete when taken with food. About 90% is bound to plasma proteins. It appears to undergo enterohepatic cycling. It is metabolised partly by O-demethylation, partly by N-deacylation, and unchanged drug and metabolites are partly conjugated with glucoronic acid, in man, it is excreted unchanged and as it metabolites in both urine and faeces.
No relevant information.
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