Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2019 Publisher: Morningside Healthcare Limited, Unit C, Harcourt Way, Leicester, LE19 1WP, United Kingdom
Pharmacotherapeutic group: Thyroid Hormones
ATC code: H03AA02
Liothyronine sodium is a naturally occurring thyroid hormone.
The biological action of Liothyronine sodium is quantitatively similar to that of Levothyroxine sodium, but the effects develop in a few hours and disappear within 24 to 48 hours of stopping treatment.
Liothyronine sodium is almost completely absorbed from the gastro-intestinal tract.
It is less readily bound to plasma proteins than thyroxine. About 0.5% is in the unbound form.
The half-life of liothyronine in euthroidism is 1 to 2 days. Thyroid hormones do not readily cross the placenta. Minimal amounts are excreted in breast milk.
There are no preclinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.
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