Source: Υπουργείο Υγείας (CY) Revision Year: 2017 Publisher: MEDOCHEMIE LTD, 1-10 Constantinoupoleos street, 3011 Limassol, Cyprus
Pharmacotherapeutic group: Benzodiazepine derivatives, Anxiolytics
ATC code: N05BA06
Lorazepam is a short acting benzodiazepine with anxiolytic, sedative, hypnotic and muscle relaxant properties.
Lorazepam is almost completely absorbed from the gastrointestinal tract and peak serum levels are reached in 2 hours. It is metabolised by a simple one-step process to a pharmacologically inert glucuronide. There are no major active metabolites.
The elimination half-life is about 12 hours and there is minimal risk of excessive accumulation. At clinically relevant concentrations, lorazepam is approximately 90% bound to plasma proteins.
Oesophageal dilation occurred in rats treated with lorazepam for more than one year at 6 mg/kg/day.
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