Source: Υπουργείο Υγείας (CY) Revision Year: 2018 Publisher: Medochemie Ltd, 1-10 Constantinoupoleos Street, 3011 Limassol, Cyprus
Pharmacotherapeutic group: Tetracyclines
ATC Code: J01 AA02.
Doxycycline is primarily bacteriostatic and is believed to exert its antimicrobial effect by the inhibition of protein synthesis. Doxycycline is active against a wide range of Gram-positive and Gram-negative bacteria and certain other micro-organisms. Doxycycline has a high degree of lipid solubility and a low affinity for calcium. It is highly stable in normal human serum. Medomycin will not degrade into an epianhydro form.
Tetracyclines are readily absorbed and are bound to plasma proteins in varying degrees. They are concentrated by the liver in the bile and excreted in the urine and faeces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral administration. Studies reported to date indicate that the absorption of doxycycline, unlike certain other tetracyclines, is not notably influenced by the ingestion of food or milk. Following a 200mg dose, normal adult volunteers averaged peak serum levels of 2.6 micrograms/ml of doxycycline at 2 hours decreasing to 1.45 micrograms/ml at 24 hours.
Studies have shown no significant difference in serum half-life of Medomycin (range 18 to 22 hours) in individuals with normal or severely impaired renal function.
Haemodialysis does not alter the serum half-life of Medomycin.
Studies have shown no significant difference in serum half-life of Medomycin (range 18 to 22 hours) in individuals with normal or severely impaired renal function.
Haemodialysis does not alter the serum half-life of Medomycin.
Not applicable.
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