Source: Υπουργείο Υγείας (CY) Revision Year: 2007 Publisher: Marketing License Holder: Medilink Pharmaceuticals Ltd., 30 Armenias, 2003 Strovolos, Nicosia, Cyprus Manufacturer: Eisai Co. Ltd., 4-6-10 Koishikawa, Bunkyo-ku, Tokyo, Japan
Peripheral neuropathies.
Megaloblastic anemia due to vitamin B12 deficiency.
The usual dose for adults is I ampoule (500μg of mecobalamin), administered intramuscularly or intravenously three times a week. The dose should be adjusted according to the age of patient and severity of symptoms.
The usual dose for adults is 1 ampoule (500μg of mecobalamin), administered intramuscularly or intravenously three times a week. After approximately 2 months of medication, the dose should be reduced to a single administration one ampoule at I to 3-month intervals for maintenance therapy.
There have been no reports of serious ill-effects from overdose.
3 years.
Methycobal should be stored in LPE pack (Light Protect Easy open pack) at room temperature <25°C. (If ampoules are not kept in the LPE pack, mecobalamin decomposes by light and decreases the content). Keep out of the reach of children.
Methycobal Injection 500μg (l mL)
Boxes of 10 ampoules.
METHYCOBAL injection is a clear, red liquid contained in brown ampoules (one-point-cut type).
pH: 5.3 to 7.3
Osmotic pressure ratio: About 1 (ration relative to isotonic sodium chloride solution).
Chemical name: Cp α-[α-(5,6-Dimethylbenz-IΗ-imidazolyl)]-Coß-methylcobamide
Molecular formula: C63H91CoN13Ο14P
Molecular weight: 1,344.38
Mecobalamin occurs as dark red crystals or crystalline powder. It is odorless and tasteless. It is slightly soluble in water, methanol and ethanol, and practically insoluble in acetone, ether and chloroform. It is hygroscopic and is affected by light.
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