Source: Pharmaceutical Benefits Scheme (AU) Revision Year: 2021 Publisher: Pharmacor Pty Ltd., Suite 803, Level 8, Tower A, The Zenith, 821 Pacific Highway, Chatswood, NSW 2067, Australia www.pharmacor.com.au Website: www.pharmacor.com.au Phone: 1300 138 805
Mycokem 500 – Mycophenolate mofetil.
| Pharmaceutical Form |
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Mycokem 500 are purple coloured, capsule shaped, biconvex, film coated tablets debossed ‘AHI’ on one side and ‘500’ on other side. |
Mycokem 500 contains mycophenolate mofetil 500 mg.
For the full list of excipients, see Section 6.1 List of excipients.
Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid. The chemical name for mycophenolate mofetil is 2-Morpholinoethyl(E)6(1,3-dihydro-4- hydroxy-6- methoxy-7-methyl-3-oxo-5- isobenzofuranyl)-4-methyl-4-hexenoate. It has a molecular formula of C23H31NO7 and a molecular weight of 433.50.
Mycophenolate mofetil is a white to off-white crystalline powder. It is freely soluble in dimethyl sulfoxide, tetrahydrofuran, acetone, acetonitrile, dichloromethane, and ethyl acetate; soluble in methanol and propylene carbonate; sparingly soluble in anhydrous ethanol; slightly soluble in 2-propanol, diethyl ether, and very slightly soluble in hexane. It is practically insoluble in water (43 μg/mL at pH 7.4); the solubility increases in acidic media (4.27 mg/mL at pH 3.6).
| Active Ingredient | Description | |
|---|---|---|
| Mycophenolate mofetil |
Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid (MPA). MPA is a potent, selective, uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase, and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. |
| List of Excipients |
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Mycokem 500 contains the following excipients: Microcrystalline cellulose, povidone, hydroxypropylcellulose, croscarmellose sodium, purified talc, magnesium stearate and opadry complete film coating system 03B50110 purple (PI number: 12853) includes hypromellose, titanium dioxide (CI No. 77891), macrogol 400, iron oxide red (CI77491), indigo carmine (CI73015) and iron oxide black (CI77499). |
Mycokem 500 (AUST R No. 164418) are available in blister packs of 150 Tablets.
Pharmacor Pty Ltd., Suite 803, Level 8, Tower A, The Zenith, 821 Pacific Highway, Chatswood, NSW 2067, Australia
www.pharmacor.com.au
Website: www.pharmacor.com.au
Phone: 1300 138 805
2 February 2011
| Drug | Countries | |
|---|---|---|
| MYCOKEM | Hong Kong, South Africa |
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