Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2021 Publisher: RPH Pharmaceuticals AB, Box 603, 101 32 Stockholm, Sweden
Neo-Cytamen contains Hydroxocobalamin, one of the forms of vitamin B12.
An intramuscular injection of hydroxocobalamin produces higher serum levels than the same dose of cyanocobalamin, and these levels are well maintained.
After injection of hydroxocobalamin, 90% of a 100 microgram dose and 30% of a 1000 microgram dose are retained. Vitamin B12 is extensively bound to specific plasma proteins called transcobalamins; transcobalamin II appears to be involved in the rapid transport of the cobalamins to tissues. Vitamin B12 is stored in the liver, excreted in the bile, and undergoes extensive enterohepatic recycling; part of an administered dose is excreted in the urine, most of it in the first 8 hours; urinary excretion, however, accounts for only a small fraction in the reduction of total body stores acquired by dietary means. Vitamin B12 diffuses across the placenta and also appears in breast milk.
None stated.
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