Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2014 Publisher: Amdipharm UK Limited, Capital House, 85 King William Street, London, EC4N 7BL, UK
Neomycin tablet (Neomycin sulphate BP) is indicated for pre-operative sterilisation of the bowel and may be useful in the treatment of impending hepatic coma, including portal systemic encephalopathy.
For oral administration.
Pre-operative sterilisation of the bowel.
Adults: 2 tablets every hour for 4 hours; then 2 tablets every 4 hours for two or three days before the operation.
Children over 12 years: 2 tablets every 4 hours for 2 or 3 days before the operation.
Children from 6 to 12 years: ½ to 1 tablet every 4 hours for 2 or 3 days before the operation.
For practical reasons, use of the tablets in children under 6 years is not recommended.
In hepatic coma, the adult dose is 4-12 gm/day in divided doses for a period of 5-7 days, whilst for children, 50-100mg/kg/day in divided doses appears appropriate. Chronic hepatic insufficiency may require up to 4gm/day over an indefinite period.
The elderly dose is the same as for adults.
In overdose, exacerbation of the adverse events reported for neomycin (nausea, diarrhoea nephrotoxicity, ototoxicity etc.) is expected.
Monitor renal and auditory function. If these are impaired, haemodialysis is indicated.
Prolonged assisted ventilation may also be required.
Shelf life: 3 years.
Store below 30°C in a dry place – protect from light.
An amber glass bottle having a tin-plate screw cap with a waxed aluminium-faced pulpboard liner. The ullage is filled with cotton wool.
Pack size: 100 tablets.
Not applicable.
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