Source: Health Products and Food Branch (CA) Revision Year: 2017
Restoration and maintenance of circulating blood volume where volume deficiency has been demonstrated, and use of a colloid is appropriate.
The choice of albumin rather than artificial colloid will depend on the clinical situation of the individual patient, according to current therapeutic recommendations.
Human albumin should always be directly administered by the intravenous route. Octalbin 25% may also be diluted in an isotonic solution (e.g. 5% glucose or 0.9% sodium chloride).
The concentration of the albumin preparation, dosage and the infusion-rate should be adjusted to the patient’s individual requirements.
The dose required depends on the size of the patient, the severity of trauma or illness and on continuing fluid and protein losses. Measures of adequacy of circulating volume and not plasma albumin levels should be used to determine the dose required.
If human albumin is to be administered, haemodynamic performance should be monitored regularly; this may include:
This product is suitable for premature infants and dialysis patients 1.
The infusion rate should be adjusted according to the individual circumstances and the indication, but should normally not exceed 1 to 2 ml/minute.
In plasma exchange the infusion rate may be higher and should be adjusted to the rate of removal.
Not applicable because Octalbin is administered in a hospital setting by health care professionals.
The solution can be directly administered by the intravenous route or it can a also be diluted in an isotonic solution (e.g. 5% glucose or 0.9% sodium chloride).
The solution should be clear or slightly opalescent. Do not use solutions which are cloudy or have deposits. This may indicate that the protein is unstable or that the solution has become contaminated.
Once the infusion container has been opened the content should be used immediately. Any unused solution should be disposed of in accordance with local requirements.
Do not use after expiry date given on the label.
Albumin solutions must not be diluted with water for injections as this may cause haemolysis in recipients. The product should be warmed to room or body temperature before use.
Hypervolaemia may occur if the dosage and rate of infusion are too high. At the first clinical signs of cardiovascular overload (headache, dyspnoea, jugular vein congestion), or increased blood pressure, raised central venous pressure and pulmonary oedema, the infusion should be stopped immediately and the patient´s haemodynamic parameters carefully monitored.
For management of a suspected drug overdose, contact your regional Poison Control Centre.
Special precautions for storage:
Store and transport at +2°C to +25°C.
Store in the original container in order to protect from light.
Do not use after expiry date.
Do not freeze.
Keep out of the reach of children!
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