Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2011 Publisher: Ferring Pharmaceuticals Ltd., Drayton Hall, Church Road, West Drayton, UB7 7PS, United Kingdom
ATC code: H01BA02
Desmopressin is an analogue of the hormone vasopressin in which the antidiuretic activity has been enhanced by the order of 10, whilst the vasopressor effect has been reduced by the order of 1500. The duration of activity has also been extended.
Like vasopressin, desmopressin also increases concentrations of Factor VIII:C, Factor VIII:Ag (vWf) and plasminogen activator (t-PA).
Following intranasal administration, the bioavailability of desmopressin is of the order of 6-10%. Peak plasma levels are achieved in approximately 50 minutes and the mean plasma half-life is about three hours.
There are no pre-clinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.
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