Revision Year: 2007 Publisher: Manufactured by: N.V. Organon, Oss, The Netherlands. For: OBS Paksitan (Pvt.) Limited., C-14, S.I.T.E., Karachi – 75700 Pakistan
Orgametril is an oral preparation of the synthetic progestagen, which shares various activities with the natural hormone progesterone. Lynestrenol has a strong progestational influence on the endometrium. In addition it suppresses the ovulation and menstruation for as long as the preparation is taken daily without interruption. Orgametril can be used in conditions requiring a pronounced progestagenic effect.
After oral administration lynestrenol is readily absorbed and subsequently converted in the liver into the pharmacologically active norethisterone. Within 2-4 hours after ingestion of lynestrenol peak plasma levels of norethisterone is reached. Lynestrenol and its metabolites are predominantly excreted in the urine, and to a lesser extent in the feces.
N.B: Through out the text, take the first day of bleeding as first day of the cycle.
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