Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2015 Publisher: Mercury Pharmaceuticals Ltd, Capital House, 85 King William Street, London EC4N 7BL, UK
Hypertensive episodes associated with Phaeochromocytoma.
Oral.
The usual starting dose is 10 mg daily. This may be increased by 10 mg daily until control of hypertensive episodes is achieved, or postural hypotension occurs. Usually the dosage required is 1-2 mg/kg body weight daily in two doses. Concomitant beta-adrenergic blockade may be necessary to control tachycardia and arrythmias notably when tumours are secreting an appreciable amount of adrenaline as well as noradrenaline.
Use with caution: 10mg daily dose should be sufficient (see Contra-Indications and Cautions below).
There is little experience in children but, doses of 1 to 2 mg/kg daily have been used successfully.
The main effect of overdosage is profound hypotension, which may last several hours, tachycardia and collapse. Treatment consists of the induction of vomiting and/or gastric lavage together with appropriate symptomatic and supportive measures.
Treat hypotension with plasma expanders and the ‘head down’ position.
Noradrenaline is of little value when α-adrenergic receptors are blocked.
Adrenaline should not be used since stimulation of β-adrenergic receptors will further increase blood pressure.
Shelf life: 24 months.
Store in a dry place and protect from light.
Polypropylene securitainers, amber glass bottles, polythene containers and blisters. (PVC/PVDC/Aluminium foil). In packs of 30 and 100.
No special instructions.
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