Source: Health Products Regulatory Authority (ZA) Revision Year: 2023 Publisher: Kiara Health (Pty) Ltd, 72 Steel Road, Spartan, Kempton Park, 1619, South Africa
Pharmacological class: A 3.1 Antirheumatics (anti-inflammatory agents)
ATC Classification: M01AC01 – oxicams
Anti-inflammatory and antirheumatic products, nonsteroids.
Piroxicam has analgesic, anti-inflammatory and anti-pyretic properties.
Piroxicam is well absorbed from the gastro-intestinal tract: peak plasma concentrations are reached 3 to 5 hours after an oral dose. It is metabolised in the liver by hydroxylation and conjugation with glucuronic acid and is excreted predominantly in the urine with smaller amounts in the faeces. Enterohepatic recycling occurs. Less than 5% of the dose is excreted unchanged. Piroxicam is extensively bound to plasma proteins (about 99%) and has a long plasma half-life of approximately 50 hours.
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