Source: Health Products Regulatory Authority (ZA) Revision Year: 2021 Publisher: Adcock lngram Limited, Address, 1 New Road, Erand Gardens, Midrand, 1685 P.O. Box Private Bag X69 Bryanston 2021
Category and class: A 2.7 Antipyretic or antipyretic and anti-inflammatory analgesics
PONSTEL is an analgesic preparation with anti-inflammatory properties. PONSTEL is known to have a peripheral anti-inflammatory effect and has also shown antipyretic action.
The pharmacological activity of PONSTEL may be due in part to its ability to inhibit the synthesis of prostaglandins. PONSTEL also inhibits the action of exogenous prostaglandins on uterine muscle, uterine tube contraction and ovarian cyclic AMP and progesterone formation in animal models.
Mefenamic acid is well absorbed from the gastro-intestinal tract. Peak plasma concentrations occur in about 2 to 4 hours, with a half-life of 2 to 4 hours. Plasma levels are proportional to dose, following multiple doses, with no drug accumulation.
Mefenamic acid is extensively bound to plasma proteins. Over 50% of the dose may be recovered in the urine as unchanged drug or conjugated metabolites.
No information available.
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