Source: FDA, National Drug Code (US) Revision Year: 2020
Methacholine chloride, the active ingredient of Provocholine, is a parasympathomimetic (cholinergic) bronchoconstrictor agent. Provocholine (methacholine chloride) powder for solution is administered by oral inhalation.
Chemically, methacholine chloride (the active ingredient) is 1-propanaminium, 2-(acetyloxy)-N,N,N,trimethyl, chloride. It is a white to practically white deliquescent compound, soluble in water, alcohol and chloroform and insoluble in ether. Aqueous solutions are neutral to litmus.
Methacholine chloride has an empirical formula of C8H18ClNO2, a molecular weight of 195.69, and the following structural formula:
Each vial of Provocholine contains 100 mg of methacholine chloride powder.
| Dosage Forms and Strengths |
|---|
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Powder for Solution: 100 mg of white to off-white crystalline powder in amber glass vials (powder is reconstituted and then diluted prior to administration). |
| How Supplied |
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Provocholine (methacholine chloride) powder for solution: in amber glass vials that contain 100 mg of methacholine chloride powder, white to off-white in color. Cartons have 6 vials (NDC 64281-100-06). Provocholine powder for solution pharmacy bulk package (not for direct use): in a plastic drum containing 1,000 g of methacholine chloride powder in a foil package (NDC 64281-100-07). Distributed by: Methapharm, Inc. Coral Springs, FL 33065. |
| Drug | Countries | |
|---|---|---|
| PROVOCHOLINE | Canada, Spain, Israel, Japan, United States |
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