Source: European Medicines Agency (EU) Revision Year: 2017 Publisher: AS GRINDEKS., Krustpils iela 53, RÄ«ga, LV-1057, Latvia, Tel.: +371 67083205, Fax: +371 67083505, E-mail: grindeks@grindeks.lv
Pharmacotherapeutic group: preparations for treatment of wounds and ulcers, other cicatrizants
ATC code: D03AX03
Dexpanthenol is converted in tissues to pantothenic acid, a component of coenzyme A (CoA) that is essential to normal epithelial function, increased fibroblast proliferation and accelerated re-epithelialization in wound healing.
This process of cell division and formation of new skin tissue restores skin elasticity and promotes wound healing.
Dexpanthenol rapidly absorbed into the skin, is immediately converted to pantothenic acid, which is widely distributed into body tissues, mainly as coenzyme A.
After topical applications pantothenic acid concentrates in hair, hair roots, nails, epidermis, and corium.
The major part of pantothenic acid is excreted unchanged in the urine and to smaller extent in faeces.
In animals, young rats fed 50mg=day as calcium pantothenate for 190 days had no adverse effects. When bred, their offspring were maintained using the same diets with no signs of abnormal growth or gross pathology. Oral dosing (500 or 2000 mg=kg body weight (bw)=day to rats, 50 mg=kg bw=day to dogs, 200-250 mg=kg bw=day to monkeys) for 6 months produced no toxic signs, weight loss, or evidence of histopathological changes at autopsy.
Low concentrations of dexpanthenol (<1%) were not toxic when applied daily for 3 months to the shaved skin of rabbits, thought they did result in slight to moderate erythema, oedema and desquamation.
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