Source: Health Products Regulatory Authority (ZA) Revision Year: 2023 Publisher: RANBAXY PHARMACEUTICALS (PTY) LTD., 14 LAUTRE ROAD, STORMILL EXT.1, ROODEPOORT 1724, SOUTH AFRICA
Category and class: A.5.7.1. Antihistaminics
Pharmacotherapeutic group: Antihistamines for systemic use
ATC code: R06AB02
RHINETON tablets contain the antihistamine, chlorpheniramine maleate. RHINETON competes reversibly with histamine for H1 receptor sites on effector cells. They suppress those symptoms due to histamine release. Antihistamines have anticholinergic properties and have a drying effect on the nasal mucosa.
Chlorpheniramine is well absorbed from the gastro-intestinal tract, following oral administration. The effects develop within 30 minutes, are maximal within 1 to 2 hours and last 4 to 6 hours. The plasma half-life has been estimated to be 12 to 15 hours.
Chlorpheniramine is metabolised to the monodesmethyl and didesmethyl derivatives. About 22% of an oral dose is excreted unchanged in the urine.
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