RIDAQ 25 mg / 50 mg Tablet Ref.[50697] Active ingredients: Hydrochlorothiazide

Source: Health Products Regulatory Authority (ZA)  Revision Year: 2023  Publisher: PHARMACARE LIMITED, Healthcare Park, Woodlands Drive, Woodmead; 2191

4.1. Therapeutic indications

RIDAQ is indicated for:

  • Oedema due to sodium and water retention. Paradoxically, RIDAQ appears to have an antidiuretic effect on patients with diabetes insipidus and may be of value in the management of the disease.
  • Essential hypertension: preferably in combination with reduced doses of specific anti-hypertensive medicines.

4.2. Posology and method of administration

Posology

Adults

For the treatment of oedema:

An initial dose of 25 mg to 100 mg is usually given, and later reduced to a smaller maintenance dose, often given on alternative days.

An initial dose of up to 200 mg may be necessary in some patients, but larger doses have no additional effect.

Adults – as an adjunct in the treatment of hypertension:

25 mg to 100 mg daily in conjunction with a reduced dose of the hypotensive medicine.

The dosage should not be higher than necessary to achieve the desired effect. Prolonged treatment may result in potassium ion loss. Potassium supplements may be necessary.

Paediatric population

2,5 mg per kg body mass daily in two divided doses.

Method of administration

For oral administration.

4.9. Overdose

Symptoms

RIDAQ can produce acute renal failure either from overdosage, producing saline depletion and hypovolaemia or, occasionally, as a result of a hypersensitivity reaction. The most frequent signs and symptoms observed are those caused by electrolyte depletion (hypokalaemia, hypochloraemia, hyponatraemia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalaemia may accentuate cardiac dysrhythmias.

Treatment

In massive overdosage, treatment should be symptomatic, supportive and directed at fluid and electrolyte replacement. In cases of recent ingestion emesis or gastric lavage should be carried out. Dehydration, electrolyte imbalance, hepatic coma and hypotension should be corrected by established procedures. If required, give oxygen or artificial respiration for respiratory impairment. The degree to which RIDAQ is removed by haemodialysis has not been established.

6.3. Shelf life

48 months.

6.4. Special precautions for storage

Store at or below 25°C.

Keep in the original packaging until required for use.

6.5. Nature and contents of container

RIDAQ-25:

14 or 28 tablets are packed in a printed, metallised, low-density polyethylene lay-flat bag and sealed with a lay-flat zip.

500 tablets are packed in a white polypropylene container, together with a white rayon and white foam insert, and sealed with a white low-density polyethylene cap.

RIDAQ-50:

500 tablets are packed in a white polypropylene container, together with a white foam insert, and sealed with a white low-density polyethylene cap.

Not all packs and pack sizes are necessarily marketed.

6.6. Special precautions for disposal and other handling

No special requirements.

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