Source: Health Products and Food Branch (CA) Revision Year: 2012
SANDOMIGRAN & SANDOMIGRAN DS – Pizotifen hydrogen malate 0.5 mg and 1 mg Pizotifen Tablets.
Sandomigran (pizotifen as hydrogen malate) is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating properties.
The mode of action of Sandomigran in preventing migraine is not fully understood but it is known to inhibit the permeability increasing effect of serotonin and histamine to control the transudation of plasmakinin across cranial vessel membranes, an effect which may alter pain thresholds. Sandomigran also inhibits serotonin re-uptake by blood platelets, impacting tonicity and decreasing passive distension of extracranial arteries.
Each ivory, sugar-coated tablet contains: 0.5 mg of pizotifen (as hydrogen malate), lactose monohydrate, corn starch, povidone, magnesium stearate, propyl paraben, acacia, colloidal silicone dioxide, cetyl palmitate, sugar and talc. Available in bottles of 100 and 500.
Each whitish with bevelled edge, scored on one side tablet contains: 1 mg of pizotifen (as hydrogen malate), lactose anhydrous, magnesium stearate, and microcrystalline cellulose. Available in bottles of 100.
| Marketing Informations | Authorization Dates |
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Authorization holder:
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| Drug | Countries | |
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| SANDOMIGRAN | Australia, Canada, Hong Kong, Netherlands, New Zealand, Turkey, South Africa |
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