SIMDAX Injection Ref.[8654] Active ingredients: Levosimendan

Each mL contains 2.5 mg of levosimendan.

Levosimendan is an inotrope agent with a unique mode of action. It is a calcium sensitizer, which increase cardiac contractility by enhancing the sensitivity of the myocardium to calcium. As a result, levosimendan produces positive inotropic effects that are independent of beta-receptors or cyclic AMP.

It also has a vasodilator effect, by opening ATP-sensitive potassium channels in vascular smooth muscles, which results in smooth muscle relaxation. The combination of inotropic and vasodilator actions results in an increased force of contraction with decreased preload and afterload in the myocardium.

Levosimendan is chemically named as (-) - (R) - [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-phenyl]hydrazono]-ropanedinitrile. It is a yellow to brownish-yellow powder with a molecular weight of 280.3, an empirical formula of C₁₄H₁₂N₆O and the following structure:

Levosimendan is a moderately lipophilic compound. Its solubility in distilled water is 0.04mg/mL, in ethanol 7.8 mg/mL, and at a pH of 8 in phosphate buffer (67 mM) 0.9mg/Ml.

For a full list of excipients, see section 6.1.