Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2020 Publisher: Actavis Group PTC ehf, ReykjavÃkurvegi 76-78, 220 Hafnarfjordur, Iceland
Pharmacotherapeutic group: R06AD02
Promethazine hydrochloride – sedative. The drug is an antihistamine with anticholinergic activity.
Promethazine hydrochloride is readily absorbed from the gastrointestinal tract, but undergoes extensive first pass metabolism in the liver. With only 25% of the oral dose reaching the systemic circulation unchanged. After oral therapy therapeutic effects are identifiable at 15-30 minutes and peak plasma concentrations at 2 to 3 hours. Estimates of terminal half-life in blood plasma have been quoted as 4-6 hours. It is extensively plasma protein bound. It is eliminated mainly as metabolites, predominantly by the faecal (via biliary) route, with <1% of the parent compound and CA 10% as the sulfoxide metabolite being excreted in the urine over a 72 hour period.
None stated.
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