Source: Health Products Regulatory Authority (IE) Revision Year: 2019 Publisher: Sanofi-Aventis Ireland Limited T/A SANOFI, Citywest Business Campus, Dublin 24, Ireland
Pharmacotherapeutic group: Antidepressants/Non-selective monoamine reuptake inhibitors
ATC code: N06AA06
Trimipramine has a potent antidepressant action similar to that of tricyclic antidepressant. It also possesses a pronounced sedative action. Trimipramine is a tricyclic antidepressant.
Trimipramine is readily absorbed after oral administration. It is strongly protein bound. It is metabolised in the liver to its metabolite dimethyltrimipramine. Trimipramine is excreted in the urine mainly in the form of its metabolites. It has a T½ of 10-25 hours.
Hepatic metabolism decreases thus lowering total clearance. Steady state concentrations, the free fraction and the half lives are increased. It is important to reduce the dose, at least in the early stages of treatment.
Reduce the dose of trimipramine.
Not relevant.
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