Source: Health Products Regulatory Authority (IE) Revision Year: 2019 Publisher: Elara Pharmaservices Europe Limited, 239 Blanchardstown Corporate Park, Ballycoolin, Dublin, Dublin, D15KV21, Ireland
Taurolin should not be used if an allergy against the active ingredient or the excipients is known or suspected.
Taurolin should not be co-administered with oxidising agents such as Dakin’s Solution, povidone iodine or hydrogen peroxide.
Long-term effects of use, particularly of repeated instillation beyond 5 days postoperatively have not yet been established.
During intra-operative application of Taurolin an increase or decrease in blood pressure or variation of the heart rate might be seen, particularly with light anaesthaesia.
Taurolin should not be co-administrated with oxidising agents, such as Dakin’s Solution, povidone iodine or hydrogen peroxide. This can cause a metabolic acidosis.
As indicated in Section 4.2, Taurolin should be used with caution in patients with renal impairment.
When co-administered with systemic antibiotics, the product has an additive (or indifferent) antimicrobial interaction with cephalosporins, ureidopenicillins and metronidazole, and synergism with aminoglycosides, in addition to neutralizing their induced bacterial endotoxin release.
Taurolidine has shown no evidence of teratogenicity in animal studies, but administration to pregnant or lactating women should only be undertaken if the clinician considers it essential.
None stated.
Taurolin is generally well-tolerated. Occasional local pain or irritation may occur in conscious, sensitive patient following the initial instillation, and can be abolished for subsequent Taurolin instillations by the pre-installation of 10 ml 0.1% lignocaine.
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via HPRA Pharmacovigilance, Earlesfort Terrace, IRL – Dublin 2; Tel: +353 1 6764971; Fax: +353 1 6762517; Website: www.hpra.ie; Email: medsafety@hpra.ie.
Taurolin should not be co-administered with oxidising agents such as Dakin’s Solution, povidone iodine or hydrogen peroxide.
This can cause metabolic acidosis.
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
