Source: FDA, National Drug Code (US) Revision Year: 2022
Terrell (isoflurane, USP), a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is:
Some physical constants are:
| Molecular weight | 184.5 |
| Boiling point at 760 mm Hg | 48.5°C |
Refractive index  | 1.2990-1.3005 |
| Specific gravity 25°/25°C | 1.496 |
| Vapor pressure in mm Hg** | |
| 20°C | 238 |
| 25°C | 295 |
| 30°C | 367 |
| 35°C | 450 |
** Equation for vapor pressure calculation:
Partition coefficients at 37°C:
| Water/gas | 0.61 |
| Blood/gas | 1.43 |
| Oil/gas | 90.8 |
Partition coefficients at 25°C – rubber and plastic:
| Conductive rubber/gas | 62.0 |
| Butyl rubber/gas | 75.0 |
| Polyvinyl chloride/gas | 110.0 |
| Polyethylene/gas | ~2.0 |
| Polyurethane/gas | ~1.4 |
| Polyolefin/gas | ~1.1 |
| Butyl acetate/gas | ~2.5 |
| Purity by gas chromatography | >99.9% |
| Lower limit of flammability in oxygen or nitrous oxide at 9 joules/sec. and 23°C | None |
| Lower limit of flammability in oxygen or nitrous oxide at 900 joules/sec. and 23°C | Greater than useful concentration in anesthesia. |
Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures), and does not attack aluminum, tin, brass, iron or copper.
| How Supplied |
|---|
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Terrell (isoflurane, USP) is packaged in 100 mL and 250 mL amber-colored bottles. 100 mL – NDC 66794-019-10 250 mL – NDC 66794-019-25 Manufactured By: Piramal Pharma Limited, N.H. 9, Digwal Village, Kohir Mandal, Kohir Cross Road, Sangareddy Dist. 502 321, Telangana, India |
| Drug | Countries | |
|---|---|---|
| TERRELL | United States, South Africa |
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