Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2020 Publisher: Mercury Pharmaceuticals Ltd, Capital House, 85 King William Street, London, EC4N 7BL, UK
Tranylcypromine is a non-hydrazine monoamine oxidase inhibitor for the treatment of symptoms of depressive illness especially where phobic symptoms are present or where treatment with other types of anti-depressants has failed. It is not recommended for mild depressive states resulting from temporary situational difficulties.
Tranylcypromine 10mg Tablets/Parnate 10mg Tablets are for oral administration only.
Initially, 1 tablet morning and afternoon. If the response is not adequate after the first week add a further tablet at midday, and continue for at least a week. A dosage of 3 tablets a day should only be exceeded with caution. When a satisfactory response has been obtained, dosage may be reduced to maintenance level often of 1 tablet a day.
When given with a tranquillizer, the dosage of ‘parnate’ is not affected when given concurrently with electroconvulsive therapy; the usual dosage is 1 tablet twice a day during the series and 1 tablet a day afterwards as maintenance therapy.
Use with great caution and at a lower dosage.
Tranylcypromine is not indicated for children under 18 years of age.
Tablets should be swallowed whole with a glass of water.
Signs and symptoms are usually of the type already described as adverse reactions, but may be more intense, may include hyperpyrexia, tremor and convulsions, and may follow a latent period. Treatment consists of the induction of vomiting and/or gastric lavage together with supportive and symptomatic measures. External cooling is recommended for hyperpyrexia. Treat hypotension with fluid replacement; if severe or persistent, noradrenaline may be considered. Hypertension, if it occurs, may be relieved by slow intravenous injection of phentolamine mesylate. Pancuronium with mechanical ventilation may help reverse muscle spasm and pyrexia. Beta-Adrenergic receptor blockade has been used successfully.
2 years.
Do not store above 25°C. Store in the original package to protect from light and moisture.
Polypropylene tablet container with a cap and security tag containing desiccant cartridge and 28 and 250 tablets.
No special requirements for disposal. Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
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