Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2020 Publisher: Zentiva Pharma UK Limited, 12 New Fetter Lane, London, EC4A 1JP, United Kingdom
Pharmacotherapeutic Group: Psychoanaleptics; Non-selective monoamine reuptake inhibitors
ATC Code: N06AA06
Trimiparamine is a tricyclic antidepressant. It has marked sedative properties.
Trimipramine undergoes high first-pass hepatic clearance, with a mean value for bioavailability of about 41% after oral administration.
The absolute volume of distribution is 31 litres/kg and total metabolic clearance is 16 ml/min/kg.
Plasma protein binding of trimipramine is about 95%. The plasma elimination half-life is around 23 hours. Trimipramine is largely metabolised by demethylation prior to conjugation yielding a glucuronide.
No additional pre-clinical data of relevance to the prescriber.
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