UBRETID Tablet Ref.[2752] Active ingredients: Distigmine

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2009  Publisher: Sanofi-aventis, One Onslow Street, Guildford, Surrey, GU1 4YS, UK

Contraindications

Ubretid is contraindicated in cases of severe post operative shock, serious circulatory insufficiency, severe constipation, serious spastic and mechanical ileus, asthma and mechanical urinary obstruction.

Special warnings and precautions for use

Caution should be taken in conditions where the potentiation of the effects of acetylcholine is undesirable, eg cardiac dysfunction, bronchospasm, peptic ulcer, oesophagitis, epilepsy and Parkinsonism. The patient should be supervised in the early stages of dosage titration to guard against the possibility of myasthenic crisis or cholinergic crisis.

Interaction with other medicinal products and other forms of interaction

Use with caution in patients receiving concomitantly drugs acting on the cardiovascular system, e.g. beta blockers, drugs with local anaesthetic properties and muscle relaxants. In myasthenia gravis, where short acting cholinergic drugs are taken concurrently, their dosage should be reduced to the minimum required to control symptoms.

Pregnancy and lactation

Ubretid should be avoided during pregnancy. No information is available on lactation.

Effects on ability to drive and use machines

None stated.

Undesirable effects

The following side effects may occur infrequently: bradycardia, AV block, hypotension, bronchospasm, dyspnoea, increased bronchial secretions, sweating, salivation and lacrimation, muscle twitching, abdominal cramps, diarrhoea, urinary frequency and miosis. These effects of Ubretid may be controlled with atropine, giving 2mg intramuscularly; atropinisation should be maintained for at least 24 hours.

Incompatibilities

None stated.

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