VELTEX Capsule / Solution for injection Ref.[51198] Active ingredients: Diclofenac

Source: Health Products Regulatory Authority (ZA)  Revision Year: 2023  Publisher: Adcock Ingram Limited, 1 New Road, Erand Gardens, Midrand, 1685

5.1. Pharmacodynamic properties

A 3.1 Antirheumatics (Anti-inflammatory agents)
ATC Code: M01AB05

VELTEX is a non-steroidal compound with antirheumatic, anti-inflammatory, analgesic and antipyretic action. In vitro its active substance strongly inhibits prostaglandin synthetase and also has an inhibitory effect on platelet aggregation. VELTEX inhibits prostaglandin biosynthesis and this inhibition has an important bearing on its mechanism of action. Prostaglandins appear to play a major role in causing inflammation, pain and fever.

5.2. Pharmacokinetic properties

Absorption

The micro-pellets contained in the VELTEX capsules will be released in the stomach and, mixed with its content, reach the intestinal tract, where the dissolution occurs slowly. Serum peak levels are achieved within 1 to 3 hours and due to the quantity of diclofenac presented in these micro-pellets an extended plasma concentration is maintained.

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