VIVOTIF Typhoid vaccine capsule Ref.[10259] Active ingredients: Typhoid, live attenuated

Vivotif (Typhoid Vaccine Live Oral Ty21a) is a live attenuated vaccine for oral administration only. The vaccine contains the attenuated strain Salmonella typhi Ty21a (1, 2).

Vivotif is manufactured by the PaxVax Berna GmbH, Switzerland. The vaccine strain is grown in fermenters under controlled conditions in medium containing a digest of yeast extract, an acid digest of casein, dextrose and galactose. The bacteria are collected by centrifugation, mixed with a stabilizer containing sucrose, ascorbic acid and amino acids, and lyophilized. The lyophilized bacteria are mixed with lactose and magnesium stearate and filled into gelatin capsules which are coated with an organic solution to render them resistant to dissolution in stomach acid. The enteric-coated, salmon/white capsules are then packaged in 4-capsule blisters for distribution. The contents of each enteric-coated capsule are shown in Table 1.

Table 1. Contents of one enteric-coated capsule of Vivotif (Typhoid Vaccine Live Oral Ty21a):

==*= Vaccine potency (viable cell counts per capsule) is determined by inoculation of agar plates with appropriate dilutions of the vaccine suspended in physiological saline.