Source: FDA, National Drug Code (US) Revision Year: 2021
Proper name: Dexrazoxane
Chemical name: (S)4,4'(1-methyl-1,2-ethanediyl)bis[2,6-piperazinedione]
Molecular formula and molecular mass: C11H16N4O4 and 268.28
Structural formula:
Physicochemical properties: ZINECARD (dexrazoxane) is a sterile, lyophilized, parenteral, cardioprotective agent for use in conjunction with anthracycline. It is a white to off-white crystalline powder.
It is sparingly soluble in water and 0.1 N HCl, slightly soluble in acetonitrile, ethanol, methanol and water/dimethylacetamide (1:1), and practically insoluble in non-polar organic solvents. Its melting range is 187-197°C. The acidic pKa value of dexrazoxane at 25°C is 2.1. The alkaline pKa’s are 10.1 and 11.1. The partition coefficient, expressed as the dexrazoxane concentration in 1-octanol divided by the aqueous phase concentration, is 0.025 at 25°C.
| Dosage Forms and Strengths |
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ZINECARD (dexrazoxane) is available in: 250 mg single dose vial, for reconstitution with recommended diluent. Diluent not provided. The 250 mg vial contains 250 mg of dexrazoxane; pH is adjusted with hydrochloric acid, NF. The 500 mg vial contains 500 mg of dexrazoxane; pH is adjusted with hydrochloric acid, NF. |
| Drug | Countries | |
|---|---|---|
| ZINECARD | Canada, United States |
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