This brand name is authorized in Nigeria.
The drug COMBICLEAR contains a combination of these active pharmaceutical ingredients (APIs):
1
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UNII
779619577M - CLOBETASOL PROPIONATE
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Clobetasol propionate, like other topical corticosteroids, has anti-inflammatory, antipruritic, and vasoconstrictive properties. Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. |
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2
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UNII
R9400W927I - KETOCONAZOLE
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Ketoconazole is an imidazole-dioxolane antimycotic, active against yeasts, including Malassezia and dermatophytes. |
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3
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UNII
057Y626693 - NEOMYCIN SULFATE
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Neomycin is an aminoglycoside antibiotic and acts by binding to polysomes, inhibiting protein synthesis and generating errors in the transcription of the genetic code. |
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This drug has been approved in Nigeria as follows:
| Identifier | Form | Presentation | Description | Approval |
|---|---|---|---|---|
| C4-0466 | Cream | COMBICLEAR CREAM CREAM 0.25 mg/g; 10 mg/g; 5000 IU/g | COMBICLEAR CREAM COMBICLEAR KETOCONAZOLE USP 10MG, CLOBETASOL PROPIONATEUSP 0.25MG, NEOMYCIN SULFATE USP EQ. TO NEOMYCIN 5000 IU POM CREAM 1 X 20GM ANTI- INFECTIVE/ CORTICOSTEROID COMBINATIONS DAITECH PHARMACEUTICALS LTD 10, FARANAH STREET WUSE ZONE 2, ABUJA BHARAT PARENTERALS LTD VILL: HARIPURA, TA. SAVIL, DIST: VADODARA 391 520 GUJARAT, INDIA GMP- RBC LR- SATIS; FEES- PAID; NP: NA 26/06/2018 R R R C4-0466 | 30/01/2020 |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| D07CD01 | Clobetasol and antibiotics | D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07C Corticosteroids, combinations with antibiotics → D07CD Corticosteroids, very potent, combinations with antibiotics |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| NG | Registered Drug Product Database | C4-0466 |
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